Gypenoside VIII

Name	ginsenoside Rd
Synonyms	ginsenoside Rd GINSENOSIDE RD GINSENOOSIDERD Gypenoside VIII Ginsenoside Rd 52705-93-8 xydammar-24-en-3-yl2-o-beta-d-glucopyranosyl- beta-d-glucopyranoside,(3-beta,12-beta)-20-(beta-d-glucopyranosyloxy)-12-hydro (3β,12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside b-D-Glucopyranoside, (3b,12b)-20-(b-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-b-D-glucopyranosyl- 2-o-beta-d-glucopyranosyl-(3beta,12beta)-20-(beta-d-glucopyranosyloxy)-12-hydroxydammara-24-en-3-yl-beta-d-glucopyranoside 2-O-beta-D-Glucopyranosyl-(3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammara-24-en-3-yl-beta-D-glucopyranoside beta-D-Glucopyranoside, (3-beta,12-beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl- (8xi,9xi,12alpha,13alpha,14beta,17beta)-17-[(1S)-1-(beta-D-glucopyranosyloxy)-1,3,5-trimethylhex-4-en-1-yl]-12-hydroxy-4,4,10,14-tetramethylgonan-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
CAS	52705-93-8
EINECS	258-118-5
InChI	InChI=1/C48H82O18/c1-21(2)15-22(3)17-48(8,66-43-40(60)37(57)34(54)28(19-50)62-43)24-11-13-47(7)23-9-10-30-45(4,5)31(12-14-46(30,6)25(23)16-26(52)32(24)47)64-44-41(38(58)35(55)29(20-51)63-44)65-42-39(59)36(56)33(53)27(18-49)61-42/h15,22-44,49-60H,9-14,16-20H2,1-8H3/t22?,23?,24-,25?,26-,27+,28+,29+,30?,31?,32+,33+,34+,35+,36-,37-,38-,39+,40+,41+,42-,43-,44-,46+,47+,48-/m0/s1

Molecular Formula	C48H82O18
Molar Mass	947.15
Density	1.38±0.1 g/cm3(Predicted)
Melting Point	204～206℃
Boling Point	1015.6±65.0 °C(Predicted)
Specific Rotation(α)	+19.38（c=1.03，methanol）
Flash Point	570.9°C
Solubility	DMSO : ≥ 100 mg/mL (105.58 mM)
Vapor Presure	0mmHg at 25°C
Appearance	White powder (ethanol-ethyl acetate 1:1)
Color	White to Off-White
pKa	12.85±0.70(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Stability	Hygroscopic
Sensitive	Easily absorbing moisture
Refractive Index	1.61
MDL	MFCD00210508
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, water, insoluble in ether, benzene, from ginseng rhizome, Gynostemma pentaphyllum.

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Safety Description	S2 - Keep out of the reach of children. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany	3
HS Code	29389090

plant source:	ginseng
overview	ginsenoside (Ginsenoside) is a steroidal compound, triterpene saponin, mainly found in ginseng medicinal materials. Ginsenoside is regarded as the active ingredient in ginseng, so it has become the research target. At present, more than 40 ginsenoside monomers have been isolated and identified.
component	the equivalent of Rg1, Rb1 and Rc in ginsenoside monomer compounds is higher, while Rd, Rg3 and Rh2 are rare saponins, but their pharmacological activity is better than that of major ginsenosides. Among them, ginsenoside Rd is one of the main forms of absorption and utilization in intestinal tract after main saponin metabolism, which has good pharmacological effects on nervous system, cardiovascular and cerebrovascular functions and renal functions.
Target	Value
COX-2 ()
iNOS ()
Ca2+ influx ()
NF-κB (in HepG2 cells)	12.05 μM
CYP2D6 (Cell-free assay)	58.0 μM
use	used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: anti-peroxidation activity, inhibition of cAMP phosphodiesterase activity, promotion of plasma secretion of corticosterone activity, antiarrhythmic effect, antiviral activity, regulation of renal function, vasodilator effect. ginsenoside Rd is a protopanaxadiol saponin, which has a variety of effects in vitro and in vivo, including cardiovascular and neuroprotective, anti-inflammatory, etc.

Last Update：2024-04-09 21:54:55

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